Say Goodbye to Tired Eyes: PRF vs. PDGF Under-Eye Treatments Explained
Kasey BennettIf you’ve ever looked in the mirror and thought, “Why do I look so tired?”—even when you’re not—your under-eye area might be to blame. Dark circles, puffiness, and fine lines are common concerns that many patients face. Luckily, there are two incredible, natural options to brighten and rejuvenate this area: PRF (Platelet-Rich Fibrin) and PDGF (Platelet-Derived Growth Factor).
As a nurse practitioner, I love helping patients understand the differences between these two treatments and decide which is best for their skin goals.
What Is PRF for Under-Eyes?
PRF is a regenerative treatment made using your own blood. After a quick blood draw, we spin it down to isolate a golden serum rich in platelets, stem cells, and fibrin. This serum is then carefully injected under the eyes to reduce puffiness, smooth texture, and restore volume naturally.
Because PRF uses your body’s own healing cells, it’s a safe and natural alternative to traditional fillers. Over time, it helps stimulate collagen, brighten dark circles, and restore a fresh, well-rested look.
What Is PDGF for Under-Eyes?
PDGF stands for Platelet-Derived Growth Factor, and it’s essentially a lab-created version of the growth factors your body naturally produces. What makes PDGF unique is its consistency and potency. While PRF relies on what your body produces in the moment—which can vary based on hydration, sleep, stress, or recent illness—PDGF delivers a reliable, high concentration of growth factors every time. In fact, it can be up to 1,000 to 300,000 times more concentrated than what’s typically found in PRF.
Another major bonus? No blood draw is required. This makes PDGF a convenient option for patients who prefer not to undergo a blood collection process.
PDGF can also help restore volume under the eyes—just like PRF—but with a predictable and controlled formulation. It's ideal for those looking to firm, smooth, and rejuvenate the delicate under-eye area with a powerful and effective growth factor-based approach.
PRF vs. PDGF: Which One Is Right for You?
While both PRF and PDGF work to refresh and revive the under-eye area, they offer slightly different benefits:
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PRF is great for those who want a fully natural option using their own biology.
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PDGF offers a more consistent, concentrated treatment without the need for a blood draw.
Some patients even combine both treatments to target different aspects of under-eye aging—like volume loss, crepiness, and pigmentation—for enhanced results.
Who Can Benefit from These Treatments?
If you're tired of looking tired, both PRF and PDGF offer safe, non-surgical options to refresh your under-eye area. Whether you’re looking for more brightness, fewer lines, or improved texture, these regenerative treatments are gentle, effective, and tailored to your needs.
Let’s find the best option for your goals—and get you back to glowing.
Role of platelet-derived growth factors in physiology and medicine