Platelet rich fibrin (PRF) is the liquid portion of your blood, known as plasma. Plasma is mostly water, but the specific method of centrifugation of the blood for PRF leads the plasma to contain a high concentration of platelets, mesenchymal stem cells, and fibrin. These components encourage healing and remodeling of the tissue where the product is injected, causing increased collagen stimulation, elastin production, and increased blood flow to this area.